{"id":11185,"date":"2020-04-24T16:58:10","date_gmt":"2020-04-24T14:58:10","guid":{"rendered":"https:\/\/www.instrument-solutions.com\/uncategorized\/is-your-spectrophotometer-compiant-with-the-latest-usp-and-ep-chapters.html"},"modified":"2020-04-28T11:08:19","modified_gmt":"2020-04-28T09:08:19","slug":"is-your-spectrophotometer-compiant-with-the-latest-usp-and-ep-chapters","status":"publish","type":"post","link":"https:\/\/www.instrument-solutions.com\/en\/news-en\/is-your-spectrophotometer-compiant-with-the-latest-usp-and-ep-chapters.html","title":{"rendered":"Is your spectrophotometer compiant with the latest USP and EP Chapters?"},"content":{"rendered":"

New editions of United States General Pharmacopeia Chapter <857> and European Pharmacopoeia Chapter 2.2.25, giving guidance on instrument qualification for ultraviolet and visible spectrophotometry, have recently been published. The former becomes mandatory on 1st December 2019 and the latter on 1st January 2020. Both introduce new approaches to qualification and suggest a variety of new reference materials for qualification measurements. While there are several areas of conformity between the two new standards, there are also some important differences.<\/p><\/div>\n

\"\"<\/p><\/div>\n

What do they have in common?<\/strong><\/p>\n

Earlier versions of both standards contained a fairly limited set of tests to control an instrument\u2019s performance for wavelength<\/strong>, absorbance<\/strong>, stray light<\/strong> and resolution<\/strong> (spectral bandwidth). Provided an instrument passed these tests it could be claimed that it was \u2018pharmacopoeia compliant\u2019. The limitation of this approach is that a qualification carried out under one set of operating conditions might not be valid under another set. A simple example would be a qualification carried out in the visible using one light source when the actual analysis was to be carried out in the UV region using a different source. While the same parameters must still be qualified, the requirement is now to demonstrate \u2018fitness for purpose\u2019, namely that the instrument has the performance to undertake the actual analysis to the required accuracy and precision. The user must therefore determine, for these four parameters, the range over which the system will be used in the actual analysis and prove compliance over that range. One consequence of this is that the simplistic approach often adopted in the past – one qualification test for each of the four parameters – may not suffice. Both standards now recommend, directly or by implication, that the values of the references used for qualification should \u2018bracket\u2019 the values to be used in the proposed analysis, which may mean that more than one reference is required. There is also a specific new requirement, in both standards, to qualify absorbance linearity: this will almost certainly require the use of more than one absorbance reference. To help meet these new requirements, additional reference materials are cited in both standards. Both standards also allow – the USP strongly advocates – the use of commercially available Certified Reference Materials.<\/p>\n

How do they differ?<\/strong><\/p>\n

The major difference between the two new standards is their scope. Whereas USP <857> is limited to UV-visible spectrophotometers as described in USP <1857>, the new EP standard is extended to encompass HPLC UV detectors and PAT (process analytical technology) applications. This is a considerable divergence \u2013 USP <857> specifi cally excludes HPLC detectors from its scope whereas EP 2.2.25 will be mandatory for HPLC detectors. The following notes relate to spectrophotometers: HPLC is covered separately.<\/p>\n

Another major difference is in the approach to the test materials to be used for qualifi cation. The USP states: \u2018Whenever possible, certifi ed reference materials (CRMs) are to be used in preference to laboratory-prepared solutions\u2019 and now lists a greater variety of commercially available CRMs to make it easier to establish \u2018fi tness for purpose\u2019 over a range of operating parameters. The EP, conversely, gives details for the preparation of relatively few test solutions, one of which (caffeine) is not available commercially as a CRM. Fortunately, however, it still allows the use of Certifi ed Reference Materials, so compliance can still be achieved without the need to prepare solutions in the laboratory.<\/p><\/div>\n

Will I need new reference materials?<\/strong><\/p>\n

Most laboratories working in a regulated environment will already have a selection of references for instrument qualification. To determine if any additional references are needed to meet \"\"the new regulations the wavelength and absorbance values expected in the proposed analyses should be checked to see if they are encompassed by the available references. If not, additional references will be required. For example, holmium oxide<\/strong> solution is the most widely used wavelength reference, with 14 peaks covering wavelengths from 240 nm to 650 nm<\/strong>. Provided the wavelengths to be used for analysis lie within these limits, no additional wavelength references should be required. For wavelengths below 240 nm<\/strong>, however, both standards now recommend cerium oxide<\/strong> solution, covering 200 nm to 270 nm. For even lower wavelengths, a \u2018Deep UV<\/strong>\u2019 CRM is available from Starna Scientific<\/a> (Hainault UK), with certified wavelength and absorbance values down to 191 nm. When including analysis above 650 nm<\/strong>, didymium oxide<\/strong> is frequently used.<\/p>\n

For absorbance qualification, the new linearity specifications mean that more than one reference will almost certainly be required: the USP recommends that linearity is controlled at a minimum of three absorbance levels over the expected range. Potassium dichromate<\/strong> solution has been used for many years and covers wavelengths from 235 to 350 nm. For lower wavelengths, nicotinic acid<\/strong> is now recommended, covering 210-270 nm. Both are commercially available as CRMs, at a range of concentrations with absorbance values up to 3A and can be purchased in convenient \u2018linearity sets\u2019. For the visible region, the USP now lists metal-on-quartz filters; while not compatible with all instruments, these filters can be used over a wide wavelength range (250 to 850 nm). For the visible region, wellestablished neutral density<\/strong> (grey glass) filters are available.<\/p>\n

Stray light qualification: whereas EP 2.2.25 formerly named just one stray light reference, potassium chloride solution, both standards now list several references covering wavelengths from 190 nm to 400 nm. Note that USP <857> now permits the use of the traditional \u201cspecified wavelength\u201d method as well as the \u2018filter ratio\u2019 or Mielenz method<\/strong> cited in the 2015 edition.<\/p>\n

Both standards recommend the well-established toluene-in-hexane<\/strong> solution for resolution (bandwidth) qualification.<\/p>\n

Other than the references named in the standards, a wide range of CRMs for spectrophotometry is available (see table below):<\/p><\/div>\n

\"\"

Wavelengh range of Certified Reference Materials<\/p><\/div>\n

HPLC and PAT<\/strong><\/p>\n

The inclusion of these applications of UV-visible spectrophotometry in EP 2.2.25 requires different qualification
\nprocedures from conventional spectrophotometry. All the references discussed above are available either as sealed
\nsolution cells or solid filters and therefore involve no manipulation other than insertion in the instrument\u2019s sample
\nholder. A few HPLC detectors can accept a conventional solution cell or filter, but for others and for PAT applications, it will be necessary to physically transfer the test solution into the measurement cell. Three of the references mentioned above, namely cerium oxide<\/strong>, holmium oxide<\/strong> and nicotinic acid<\/strong> solutions, are available as CRMs in vial format for this purpose and were developed specifically for HPLC. A fourth, Starna Green<\/strong>, can be used for both wavelength<\/strong> and absorbance qualification<\/strong> and is a specially formulated dye mixture that is
\nvery stable, non-toxic and REACH compliant.<\/p>\n

Conclusions<\/strong><\/h2>\n

The new editions of USP <857> and EP 2.2.25 take a more holistic approach to the qualifi cation of UV-visible spectrophotometers, which must now be performed under conditions that approximate as closely as possible to those to be used for analysis. While some aspects of the new regulations may appear contradictory, the judicious selection of Certifi ed Reference Materials will allow instrument users to comply with the new regulations.<\/p>\n

Credits for this article go to Nathan Hulme, Starna Scientific Ltd<\/a>, who wrote this article. It is originally published on www.labmate-online.com.<\/a><\/p>\n

If you have any questions about standards for your spectrophotometer or would like a quote, please call us on +31 (0) 88 46 78 786 or complete this form.<\/p><\/div>\n

<\/span>More information about Starna Certified Reference Material<\/span><\/a><\/div>\n

\u00a0<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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